CRAB-17

CRAB-17

CRAB-17 is a Classification of a specific type of regulatory T cell that expresses the protEIN CRAB (Cytokine Response and Activation Binding) in response to inflammatory cytokines. These cells play a crucial role in immune regulation and are involved in maintaining immune homEOStasis.

CRAB-17 cells are characterized by their ability to modulate immune responses, particularly in autoimmune diseases and during chronic infections. They can suppress overactive immune responses, thus preventing tissue damage.

Examples and Cases:

• Example 1: In a study on rheumatoid arthritis, increased levels of CRAB-17 were associated with reduced joint inflammation.
• Example 2: Research indicates that CRAB-17 cells may be beneficial in transplant settings by preventing graft-versus-host disease.
• Case Study: A clinical trial examined CRAB-17’s role in type 1 diabetes, showing that these cells can help preserve pancreatic Beta-cell function.